Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence.

A, Ramazani; A, Rezaei

doi:10.1021/ol100931q

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Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence.

Shared by NobleBlocks on Jun 1, 2010 • 12:00 AM UTC

Authors:

Ramazani A

Rezaei A

Abstract

A novel and efficient method has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives using (N-isocyanimino)triphenylphosphorane, a secondary amine, a carboxylic acid, and an aromatic aldehyde in CH(2)Cl(2) at ambient temperature in high yields without using any catalys...

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