Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Yu, Seong-Woon; Wang, Hongmin; F. Poitras, Marc; Coombs, Carmen; J. Bowers, William; J. Federoff, Howard; G. Poirier, Guy; M. Dawson, Ted; L. Dawson, Valina

doi:10.1126/science.1072221

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Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Shared by NobleBlocks on Jul 12, 2002 • 12:00 AM UTC

Authors:

Seong-Woon Yu

Hongmin Wang

Marc F. Poitras

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. We show that PARP-1 activation is required for tr...

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