Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1).

Lacerda Bueno, Lilian; Pereira Lobo, Francisco; Guimarães Morais, Cristiane; Carvalho Mourão, Luíza; Andrez Machado de Ávila, Ricardo; Silva Soares, Irene; Jesus Fontes, Cor; Vinícius Lacerda, Marcus; Chavez Olórtegui, Carlos; Castanheira Bartholomeu, Daniella; Toshio Fujiwara, Ricardo; Martins Braga, Erika

doi:10.1371/journal.pone.0021289

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Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1).

Shared by NobleBlocks on Jan 1, 2011 • 12:00 AM UTC

Authors:

Lilian Lacerda Bueno

Francisco Pereira Lobo

Cristiane Guimarães Morais

Abstract

Apical membrane antigen 1 (AMA-1) is considered to be a major candidate antigen for a malaria vaccine. Previous immunoepidemiological studies of naturally acquired immunity to Plasmodium vivax AMA-1 (PvAMA-1) have shown a higher prevalence of specific antibodies to domain II (DII) of AMA-1. In the p...

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