Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.

S, Orita; T, Ishikawa; M, Miyagi; N, Ochiai; G, Inoue; Y, Eguchi; H, Kamoda; G, Arai; T, Toyone; Y, Aoki; T, Kubo; K, Takahashi; S, Ohtori

doi:10.1186/1471-2474-12-134

Public

Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain.

Shared by NobleBlocks on Jun 16, 2011 • 12:00 AM UTC

Authors:

Orita S

Ishikawa T

Miyagi M

Abstract

<h4>Background</h4>The exact mechanism of knee osteoarthritis (OA)-associated pain is unclear, whereas mixed evidence of inflammatory pain and neuropathic pain has been noted. We aimed to investigate pain-related sensory innervation in a monoiodoacetate (MIA)-induced model of OA.<h4>Methods</h4>Sixt...

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