Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of <i>FCGR2B</i> to genetic susceptibility

Kyogoku, Chieko; M. Dijstelbloem, Hilde; Tsuchiya, Naoyuki; Hatta, Yoko; Kato, Hitoshi; Yamaguchi, Akihiro; Fukazawa, Toru; Jansen, Marc; Hashimoto, Hiroshi; G. J. van de Winkel, Jan; G. M. Kallenberg, Cees; Tokunaga, Katsushi

doi:10.1002/art.10257

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Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of <i>FCGR2B</i> to genetic susceptibility

Published in Arthritis & Rheumatism • May 1, 2002

Authors:

Chieko Kyogoku

Hilde M. Dijstelbloem

Naoyuki Tsuchiya

Abstract

OBJECTIVE: Human low-affinity Fcgamma receptors (FcgammaR) constitute a clustered gene family located on chromosome 1q23, that consists of FcgammaRIIA, IIB, IIC, IIIA, and IIIB genes. FcgammaRIIB is unique in its ability to transmit inhibitory signals, and recent animal studies demonstrated a role f...

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Open Access

Subject

Genotyping

Single-nucleotide polymorphism

Genotype

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