Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway.

Ke, Bibo; Buelow, Roland; Shen, Xiu-Da; Melinek, Judy; Amersi, Farin; Gao, Feng; Ritter, Thomas; Volk, Hans-Dieter; W Busuttil, Ronald; W Kupiec-Weglinski, Jerzy

doi:10.1089/104303402320138970

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Heme oxygenase 1 gene transfer prevents CD95/Fas ligand-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway.

Shared by NobleBlocks on Jul 1, 2002 • 12:00 AM UTC

Authors:

Bibo Ke

Roland Buelow

Xiu-Da Shen

Abstract

Apoptosis via the CD95/FasL (CD95L) pathway plays an important role in allograft rejection. Heme oxygenase 1 (HO-1), a stress-responsive cytoprotective molecule, may be essential in preventing graft rejection. We used Ad-HO-1 gene transfer to analyze HO-1-mediated effects in a rat allogeneic orthoto...

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