Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin.

JH, Zuo; W, Zhu; MY, Li; XH, Li; H, Yi; GQ, Zeng; XX, Wan; QY, He; JH, Li; JQ, Qu; Y, Chen; ZQ, Xiao

doi:10.1002/jcb.23175

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Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin.

Shared by NobleBlocks on Sep 1, 2011 • 12:00 AM UTC

Authors:

Zuo JH

Zhu W

Li MY

Abstract

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell invasion and metastasis still need to be elucidated. In this study, we showed that activation of EGFR by EGF in HNSCC cell line SCC1...

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