Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

de la Moureyre C, Spire-Vayron; H, Debuysere; B, Mastain; E, Vinner; D, Marez; Guidice JM, Lo; D, Chevalier; S, Brique; K, Motte; JF, Colombel; D, Turck; C, Noel; RM, Flipo; A, Pol; M, Lhermitte; JJ, Lafitte; C, Libersa; F, Broly

doi:10.1038/sj.bjp.0702152

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Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

Shared by NobleBlocks on Oct 1, 1998 • 12:00 AM UTC

Authors:

Spire-Vayron de la Moureyre C

Debuysere H

Mastain B

Abstract

1. Characterization of allelic variants of the TPMT gene (TPMT) responsible for changes in TPMT activity, and elucidation of the mechanism by which these alleles act, are required because of the clinical importance of this polymorphism for patients receiving thiopurine drugs. 2. We defined the mutat...

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