Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication.

CD, Lee; M, Ott; SP, Thyagarajan; DA, Shafritz; RD, Burk; S, Gupta

doi:10.1046/j.1365-2362.1996.410595.x

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Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication.

Shared by NobleBlocks on Dec 1, 1996 • 12:00 AM UTC

Authors:

Lee CD

Ott M

Thyagarajan SP

Abstract

The Phyllanthus amarus plant shows potential for treating hepatitis B virus. To define the mechanism of action of P. amarus, we used HepG2 2.2.15 cells, which support hepatitis B virus replication. P. amarus inhibited hepatitis B virus polymerase activity, decreased episomal hepatitis B virus DNA co...

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