Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

Uchino, H; Matsumura, Yasuhiro; Negishi, Takahito; Koizumi, Fumiaki; Hayashi, T; Honda, Takashi; Nishiyama, Nobuhiro; Kataoka, Kazunori; Naito, S; Kakizoe, Tadao

doi:10.1038/sj.bjc.6602772

Public

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats

Shared by NobleBlocks on Sep 1, 2005 • 12:00 AM UTC

Authors:

H Uchino

Yasuhiro Matsumura

Takahito Negishi

Abstract

In spite of the clinical usefulness of cisplatin (CDDP), there are many occasions in which it is difficult to continue the administration of CDDP due to its nephrotoxicity and neurotoxicity. We examined the incorporation of CDDP into polymeric micelles to see if this allowed the resolution of these ...

Subject

Cisplatin

Neurotoxicity

Nephrotoxicity

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