Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

Nishisho, Isamu; Nakamura, Yusuke; Miyoshi, Yasuo; Miki, Yoshio; Ando, Hiroshi; Horii, Akira; Koyama, Kumiko; Utsunomiya, Joji; Baba, Shozo; Hedge, Philip; Markham, Alex; J. Krush, Anne; Petersen, Gloria; R. Hamilton, Stanley; C. Nilbert, Mef; B. Levy, Daniel; M. Bryan, Tracy; C. Preisinger, Antonette; J. Smith, Kelly; Su, Li-Kuo; W. Kinzler, Kenneth; Vogelstein, Bert

doi:10.1126/science.1651563

Public

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

Shared by NobleBlocks on Aug 9, 1991 • 12:00 AM UTC

Authors:

Isamu Nishisho

Yusuke Nakamura

Yasuo Miyoshi

Abstract

Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are tight...

Discussions