Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.

Q, Zhou; ME, Munger; RG, Veenstra; BJ, Weigel; M, Hirashima; DH, Munn; WJ, Murphy; M, Azuma; AC, Anderson; VK, Kuchroo; BR, Blazar

doi:10.1182/blood-2010-10-310425

Public

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.

Shared by NobleBlocks on Mar 8, 2011 • 12:00 AM UTC

Authors:

Zhou Q

Munger ME

Veenstra RG

Abstract

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8(+) T cells in...

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