Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.

H, Daitoku; M, Hatta; H, Matsuzaki; S, Aratani; T, Ohshima; M, Miyagishi; T, Nakajima; A, Fukamizu

doi:10.1073/pnas.0400593101

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.

Shared by NobleBlocks on Jun 25, 2004 • 12:00 AM UTC

Authors:

Daitoku H

Hatta M

Matsuzaki H

Abstract

Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2). Genetic studies demonstrate that Sir2 acts to extend lifespan in Caenorhabditis elegans upstream of DAF-16, a member of the FOXO family, in the i...

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