Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura.

C, Klaus; B, Plaimauer; JD, Studt; F, Dorner; B, Lämmle; PM, Mannucci; F, Scheiflinger

doi:10.1182/blood-2003-12-4165

Public

Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura.

Shared by NobleBlocks on Feb 19, 2004 • 12:00 AM UTC

Authors:

Klaus C

Plaimauer B

Studt JD

Abstract

Severe deficiency of the von Willebrand factor (VWF)-cleaving protease ADAMTS13 can lead to thrombotic thrombocytopenic purpura (TTP), a disease associated with the widespread formation of platelet-rich thrombi in many organs. Autoantibodies that inactivate ADAMTS13 are the most frequent cause of ac...

Discussions