Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.

M, Taniguchi; K, Kitatani; T, Kondo; M, Hashimoto-Nishimura; S, Asano; A, Hayashi; S, Mitsutake; Y, Igarashi; H, Umehara; H, Takeya; J, Kigawa; T, Okazaki

doi:10.1074/jbc.m112.416552

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Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway.

Shared by NobleBlocks on Oct 3, 2012 • 12:00 AM UTC

Authors:

Taniguchi M

Kitatani K

Kondo T

Abstract

The role of "sphingolipid rheostat" by ceramide and sphingosine 1-phosphate (S1P) in the regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid deprivation (AA(-)) caused autophagy with an increase in acid sphingomyleinase (SMase) activity and ceramide, which serves as an...

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