H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phase.

Centromeres are key regions of eukaryotic chromosomes that ensure proper chromosome segregation at cell division. In most eukaryotes, centromere identity is defined epigenetically by the presence of a centromeric histone H3 variant CenH3, called CENP-A in humans. How CENP-A is incorporated and repro... View More