Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.

Nakano, H; Shindo, M; Sakon, S; Nishinaka, S; Mihara, M; Yagita, H; Okumura, K

doi:10.1073/pnas.95.7.3537

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Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.

Shared by NobleBlocks on Mar 31, 1998 • 12:00 AM UTC

Authors:

H Nakano

M Shindo

S Sakon

Abstract

NF-kappaB is activated by various stimuli including inflammatory cytokines and stresses. A key step in the activation of NF-kappaB is the phosphorylation of its inhibitors, IkappaBs, by an IkappaB kinase (IKK) complex. Recently, two closely related kinases, designated IKKalpha and IKKbeta, have been...

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