Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.

Y, Hu; V, Baud; M, Delhase; P, Zhang; T, Deerinck; M, Ellisman; R, Johnson; M, Karin

doi:10.1126/science.284.5412.316

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.

Shared by NobleBlocks on Apr 1, 1999 • 12:00 AM UTC

Authors:

Hu Y

Baud V

Delhase M

Abstract

The oligomeric IkappaB kinase (IKK) is composed of three polypeptides: IKKalpha and IKKbeta, the catalytic subunits, and IKKgamma, a regulatory subunit. IKKalpha and IKKbeta are similar in structure and thought to have similar function-phosphorylation of the IkappaB inhibitors in response to proinfl...

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