Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

RA, Fridell; C, Wang; JH, Sun; DR 2nd, O'Boyle; P, Nower; L, Valera; D, Qiu; S, Roberts; X, Huang; B, Kienzle; M, Bifano; RE, Nettles; M, Gao

doi:10.1002/hep.24594

Public

Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

Shared by NobleBlocks on Dec 1, 2011 • 12:00 AM UTC

Authors:

Fridell RA

Wang C

Sun JH

Abstract

<h4>Unlabelled</h4>The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (M...

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