Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients.

JL, Macpherson; MP, Boyd; AJ, Arndt; AV, Todd; GC, Fanning; JA, Ely; F, Elliott; A, Knop; M, Raponi; J, Murray; W, Gerlach; LQ, Sun; R, Penny; GP, Symonds; A, Carr; DA, Cooper

doi:10.1002/jgm.705

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Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients.

Shared by NobleBlocks on May 1, 2005 • 12:00 AM UTC

Authors:

Macpherson JL

Boyd MP

Arndt AJ

Abstract

<h4>Background</h4>An anti-HIV-1 tat ribozyme, termed Rz2, has been shown to inhibit HIV-1 infection/replication and to decrease HIV-1-induced pathogenicity in T-lymphocyte cell lines and normal peripheral blood T-lymphocytes. We report here the results of a phase I gene transfer clinical trial usin...

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