Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation.

Ianni M, Di; F, Falzetti; A, Carotti; A, Terenzi; F, Castellino; E, Bonifacio; Papa B, Del; T, Zei; RI, Ostini; D, Cecchini; T, Aloisi; K, Perruccio; L, Ruggeri; C, Balucani; A, Pierini; P, Sportoletti; C, Aristei; B, Falini; Y, Reisner; A, Velardi; F, Aversa; MF, Martelli

doi:10.1182/blood-2010-10-311894

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation.

Shared by NobleBlocks on Feb 3, 2011 • 12:00 AM UTC

Authors:

Di Ianni M

Falzetti F

Carotti A

Abstract

Hastening posttransplantation immune reconstitution is a key challenge in human leukocyte antigen (HLA)-haploidentical hematopoietic stem-cell transplantation (HSCT). In experimental models of mismatched HSCT, T-regulatory cells (Tregs) when co-infused with conventional T cells (Tcons) favored postt...

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