Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.

CM, Pratt; S, Ruberg; J, Morganroth; B, McNutt; J, Woodward; S, Harris; J, Ruskin; L, Moye

doi:10.1016/s0002-8703(96)90525-6

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Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: distinguishing a drug effect from spontaneous variability.

Shared by NobleBlocks on Mar 1, 1996 • 12:00 AM UTC

Authors:

Pratt CM

Ruberg S

Morganroth J

Abstract

The primary goal of this investigation was to describe the effect of terfenadine on the QT interval corrected for heart rate (QTc) of the scalar electrocardiogram (ECG). The design was double-blind, four-period crossover, dose escalation, which involved 28 normal healthy volunteers and 28 patients w...

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