Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant.

GJ, LaRosa; JP, Davide; K, Weinhold; JA, Waterbury; AT, Profy; JA, Lewis; AJ, Langlois; GR, Dreesman; RN, Boswell; P, Shadduck

doi:10.1126/science.2392685

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Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant.

Shared by NobleBlocks on Aug 1, 1990 • 12:00 AM UTC

Authors:

LaRosa GJ

Davide JP

Weinhold K

Abstract

The principal neutralizing determinant (PND) of human immunodeficiency virus HIV-1 is part of a disulfide bridged loop in the third variable region of the external envelope protein, gp120. Analysis of the amino acid sequences of this domain from 245 different HIV-1 isolates revealed that the PND is ...

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