BODIPY-based ratiometric fluorescent sensor for highly selective detection of glutathione over cysteine and homocysteine.

Niu, Li-Ya; Guan, Ying-Shi; Chen, Yu-Zhe; Wu, Li-Zhu; Tung, Chen-Ho; Yang, Qing-Zheng

doi:10.1021/ja309079f

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BODIPY-based ratiometric fluorescent sensor for highly selective detection of glutathione over cysteine and homocysteine.

Shared by NobleBlocks on Nov 21, 2012 • 12:00 AM UTC

Authors:

Li-Ya Niu

Ying-Shi Guan

Yu-Zhe Chen

Abstract

We report a ratiometric fluorescent sensor based on monochlorinated BODIPY for highly selective detection of glutathione (GSH) over cysteine (Cys)/homocysteine (Hcy). The chlorine of the monochlorinated BODIPY can be rapidly replaced by thiolates of biothiols through thiol-halogen nucleophilic subst...

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