Dioxygen activation under ambient conditions: Cu-catalyzed oxidative amidation-diketonization of terminal alkynes leading to alpha-ketoamides.

C, Zhang; N, Jiao

doi:10.1021/ja908911n

Public

Dioxygen activation under ambient conditions: Cu-catalyzed oxidative amidation-diketonization of terminal alkynes leading to alpha-ketoamides.

Shared by NobleBlocks on Jan 1, 2010 • 12:00 AM UTC

Authors:

Zhang C

Jiao N

Abstract

A novel Cu-catalyzed oxidative amidation-diketonization reaction of terminal alkynes leading to alpha-ketoamides has been developed. This chemistry offers a valuable mechanistic insight into this novel Cu catalysis via a radical process. O(2) not only participates as the ideal oxidant but also under...

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