Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis.

RR, Gonzalez; T, Fong; N, Belmar; M, Saban; D, Felsen; A, Te

doi:10.1097/01.ju.0000143192.68223.f7

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Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis.

Shared by NobleBlocks on Feb 1, 2005 • 12:00 AM UTC

Authors:

Gonzalez RR

Fong T

Belmar N

Abstract

<h4>Purpose</h4>In interstitial cystitis (IC) inflammation induces and perpetuates neurotrophic changes in the bladder, resulting in the symptoms of frequency, urgency and pain. RDP58 (NH2-arg-norleucine (nle)-nle-arg-nle-nle-nle-gly-tyr-CONH2) (Sangstat Corp., Fremont, California) is a novel synthe...

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