The conserved Wobble uridine tRNA thiolase Ctu1–Ctu2 is required to maintain genome integrity

Modified nucleosides close to the anticodon are important for the proper decoding of mRNA by the ribosome. Particularly, the uridine at the first anticodon position (U34) of glutamate, lysine, and glutamine tRNAs is universally thiolated (S 2 U34), which is proposed to be crucial for both restrictio... View More