Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes.

C, Alfaro; N, Suarez; A, Gonzalez; S, Solano; L, Erro; J, Dubrot; A, Palazon; S, Hervas-Stubbs; A, Gurpide; JM, Lopez-Picazo; E, Grande-Pulido; I, Melero; JL, Perez-Gracia

doi:10.1038/sj.bjc.6604965

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Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes.

Shared by NobleBlocks on Mar 10, 2009 • 12:00 AM UTC

Authors:

Alfaro C

Suarez N

Gonzalez A

Abstract

Vascular endothelial growth factor (VEGF) inhibits differentiation and maturation of dendritic cells (DC), suggesting a potential immunosuppressive role for this proangiogenic factor. Bevacizumab, sorafenib and sunitinib target VEGF-mediated angiogenesis and are active against several types of cance...

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