An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.

DJ, Haydon; NR, Stokes; R, Ure; G, Galbraith; JM, Bennett; DR, Brown; PJ, Baker; VV, Barynin; DW, Rice; SE, Sedelnikova; JR, Heal; JM, Sheridan; ST, Aiwale; PK, Chauhan; A, Srivastava; A, Taneja; I, Collins; J, Errington; LG, Czaplewski

doi:10.1126/science.1159961

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An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.

Shared by NobleBlocks on Sep 1, 2008 • 12:00 AM UTC

Authors:

Haydon DJ

Stokes NR

Ure R

Abstract

FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian beta-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, which inhibits FtsZ and prevents cell division. PC19...

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