Lipopolysaccharide fever is initiated <i>via</i> a capsaicin‐sensitive mechanism independent of the subtype‐1 vanilloid receptor

Devrim Dogan, M; Patel, Shreya; Y Rudaya, Alla; A Steiner, Alexandre; Székely, Miklós; A Romanovsky, Andrej

doi:10.1038/sj.bjp.0705977

Public

Lipopolysaccharide fever is initiated <i>via</i> a capsaicin‐sensitive mechanism independent of the subtype‐1 vanilloid receptor

Shared by NobleBlocks on Dec 1, 2004 • 12:00 AM UTC

Authors:

M Devrim Dogan

Shreya Patel

Alla Y Rudaya

Abstract

As pretreatment with intraperitoneal capsaicin (8‐methyl‐ N ‐vanillyl‐6‐nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel‐vanilloid receptor subtype 1 (TRPV‐1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats...

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