A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

S, Pfuhler; A, Kirst; M, Aardema; N, Banduhn; C, Goebel; D, Araki; M, Costabel-Farkas; E, Dufour; R, Fautz; J, Harvey; NJ, Hewitt; J, Hibatallah; P, Carmichael; M, Macfarlane; K, Reisinger; J, Rowland; F, Schellauf; A, Schepky; J, Scheel

doi:10.1016/j.yrtph.2010.03.012

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A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

Shared by NobleBlocks on Apr 9, 2010 • 12:00 AM UTC

Authors:

Pfuhler S

Kirst A

Aardema M

Abstract

For the assessment of genotoxic effects of cosmetic ingredients, a number of well-established and regulatory accepted in vitro assays are in place. A caveat to the use of these assays is their relatively low specificity and high rate of false or misleading positive results. Due to the 7th amendment ...

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