Differential Structural Properties of GLP-1 and Exendin-4 Determine Their Relative Affinity for the GLP-1 Receptor N-Terminal Extracellular Domain

Runge, S.; Schimmer, Susann; Oschmann, Jan; Bruun Schiødt, Christine; Møller Knudsen, Sanne; Jeppesen, Claus; Madsen, Kjeld; Lau, Jesper; Thøgersen, Henning; Rudolph, Rainer

doi:10.1021/bi062309m

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Differential Structural Properties of GLP-1 and Exendin-4 Determine Their Relative Affinity for the GLP-1 Receptor N-Terminal Extracellular Domain

Shared by NobleBlocks on Apr 20, 2007 • 12:00 AM UTC

Authors:

S. Runge

Susann Schimmer

Jan Oschmann

Abstract

Glucagon-like peptide-1 (GLP-1) and exendin-4 (Ex4) are homologous peptides with established potential for treatment of type 2 diabetes. They bind and activate the pancreatic GLP-1 receptor (GLP-1R) with similar affinity and potency and thereby promote insulin secretion in a glucose-dependent manner...

Subject

Chemistry

Ligand (biochemistry)

Circular dichroism

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