Inter-enzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures

Fu, Jinglin; Liu, Minghui; Liu, Yan; Woodbury, N.; Yan, Hao

doi:10.1021/ja300897h

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Interenzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures.

Shared by NobleBlocks on Mar 28, 2012 • 12:00 AM UTC

Authors:

Jinglin Fu

Minghui Liu

Yan Liu

Abstract

Spatially addressable DNA nanostructures facilitate the self-assembly of heterogeneous elements with precisely controlled patterns. Here we organized discrete glucose oxidase (GOx)/horseradish peroxidase (HRP) enzyme pairs on specific DNA origami tiles with controlled interenzyme spacing and positio...

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