Beta-amyloid monomers are neuroprotective.

ML, Giuffrida; F, Caraci; B, Pignataro; S, Cataldo; Bona P, De; V, Bruno; G, Molinaro; G, Pappalardo; A, Messina; A, Messina; A, Palmigiano; D, Garozzo; F, Nicoletti; F, Nicoletti; E, Rizzarelli; A, Copani

doi:10.1523/jneurosci.1736-09.2009

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Beta-amyloid monomers are neuroprotective.

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience • Aug 1, 2009

Authors:

Giuffrida ML

Caraci F

Pignataro B

Abstract

The 42-aa-long beta-amyloid protein--Abeta(1-42)--is thought to play a central role in the pathogenesis of Alzheimer's disease (AD) (Walsh and Selkoe, 2007). Data from AD brain (Shankar et al., 2008), transgenic APP (amyloid precursor protein)-overexpressing mice (Lesné et al., 2006), and neuronal c...

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