Pre-symptomatic detection of prions by cyclic amplification of protein misfolding.

C, Soto; L, Anderes; S, Suardi; F, Cardone; J, Castilla; MJ, Frossard; S, Peano; P, Saa; L, Limido; M, Carbonatto; J, Ironside; JM, Torres; M, Pocchiari; F, Tagliavini

doi:10.1016/j.febslet.2004.12.035

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Pre-symptomatic detection of prions by cyclic amplification of protein misfolding.

Shared by NobleBlocks on Jan 1, 2005 • 12:00 AM UTC

Authors:

Soto C

Anderes L

Suardi S

Abstract

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative disorders affecting humans and animals. At present, it is not possible to recognize individuals incubating the disease before the clinical symptoms appear. We investigated the effectiveness of the "Protein Misfolding Cyclic Ampli...

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