Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.

N, Takatsu; T, Matsui; Y, Murakami; H, Ishihara; T, Hisabe; T, Nagahama; S, Maki; T, Beppu; Y, Takaki; F, Hirai; K, Yao

doi:10.1111/j.1440-1746.2009.05917.x

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Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.

Shared by NobleBlocks on Jul 1, 2009 • 12:00 AM UTC

Authors:

Takatsu N

Matsui T

Murakami Y

Abstract

<h4>Background and aims</h4>Azathioprine (AZA) is associated with a high frequency of adverse reactions. We examined polymorphism of the thiopurine S-methyltransferase (TPMT) gene to determine whether the TPMT genotype would be a predictive marker for the development of adverse reactions to AZA.<h4>...

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