K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Straimer, J.; F. Gnädig, Nina; Witkowski, B.; Amaratunga, C.; Duru, V.; Ramadani, A.; A. Dacheux, Mélanie; Khim, N.; Zhang, Lei; C. Lam, Stephen; Gregory, P.; Urnov, F.; Mercereau‐Puijalon, O.; Benoit‐Vical, F.; Fairhurst, R.; Ménard, D.; Fidock, D.

doi:10.1126/science.1260867

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K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Shared by NobleBlocks on Jan 23, 2015 • 12:00 AM UTC

Authors:

Judith Straimer

Nina F. Gnädig

Benoit Witkowski

Abstract

Mechanisms propelling drug resistance If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by Sibley). Mutations in a region called the K13-propeller are predictive for artemisinin resistance in South...

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