Carboxylate directed cross-coupling reactions in the synthesis of trisubstituted benzoic acids.

IN, Houpis; C, Huang; U, Nettekoven; JG, Chen; R, Liu; M, Canters

doi:10.1021/ol802349u

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Carboxylate directed cross-coupling reactions in the synthesis of trisubstituted benzoic acids.

Shared by NobleBlocks on Dec 1, 2008 • 12:00 AM UTC

Authors:

Houpis IN

Huang C

Nettekoven U

Abstract

The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50-80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction. The directing effect can be reversed by the appropri...

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