Oocyte-Specific Deletion of
                    <i>Pten</i>
                    Causes Premature Activation of the Primordial Follicle Pool

Reddy, Pradeep; Liu, Lian; Adhikari, Deepak; Jagarlamudi, Krishna; Rajareddy, Singareddy; Shen, Yan; Du, Chun; Tang, Wenli; Hämäläinen, Tuula; L. Peng, Stanford; Lan, Zi-Jian; J. Cooney, Austin; Huhtaniemi, Ilpo; Liu, Kui

doi:10.1126/science.1152257

Public

Oocyte-Specific Deletion of <i>Pten</i> Causes Premature Activation of the Primordial Follicle Pool

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

Pradeep Reddy

Lian Liu

Deepak Adhikari

Abstract

In the mammalian ovary, progressive activation of primordial follicles from the dormant pool serves as the source of fertilizable ova. Menopause, or the end of female reproductive life, occurs when the primordial follicle pool is exhausted. However, the molecular mechanisms underlying follicle activ...

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