Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.

N, Mizushima; A, Kuma; Y, Kobayashi; A, Yamamoto; M, Matsubae; T, Takao; T, Natsume; Y, Ohsumi; T, Yoshimori

doi:10.1242/jcs.00381

Public

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.

Shared by NobleBlocks on May 1, 2003 • 12:00 AM UTC

Authors:

Mizushima N

Kuma A

Kobayashi Y

Abstract

Macroautophagy is the major intracellular degradation system delivering cytoplasmic components to the lysosome/vacuole. We have shown that, in yeast and mammalian cells, the Apg12-Apg5 protein conjugate, which is formed by a ubiquitin-like system, is essential for autophagosome formation. In yeast, ...

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