Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

Y, Shu; SA, Sheardown; C, Brown; RP, Owen; S, Zhang; RA, Castro; AG, Ianculescu; L, Yue; JC, Lo; EG, Burchard; CM, Brett; KM, Giacomini

doi:10.1172/jci30558

Public

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

Shared by NobleBlocks on May 1, 2007 • 12:00 AM UTC

Authors:

Shu Y

Sheardown SA

Brown C

Abstract

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is unkn...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!