Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.

AC, Anderson; DE, Anderson; L, Bregoli; WD, Hastings; N, Kassam; C, Lei; R, Chandwaskar; J, Karman; EW, Su; M, Hirashima; JN, Bruce; LP, Kane; VK, Kuchroo; DA, Hafler

doi:10.1126/science.1148536

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Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.

Shared by NobleBlocks on Nov 1, 2007 • 12:00 AM UTC

Authors:

Anderson AC

Anderson DE

Bregoli L

Abstract

CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-...

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