Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.

CE, Cano; J, Gommeaux; S, Pietri; M, Culcasi; S, Garcia; M, Seux; S, Barelier; S, Vasseur; RP, Spoto; MJ, Pébusque; NJ, Dusetti; JL, Iovanna; A, Carrier

doi:10.1158/0008-5472.can-08-2320

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Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.

Shared by NobleBlocks on Jan 1, 2009 • 12:00 AM UTC

Authors:

Cano CE

Gommeaux J

Pietri S

Abstract

p53 exerts its tumor suppressor function mainly through transcriptional induction of target genes involved in several processes, including cell cycle checkpoints, apoptosis, and regulation of cell redox status. p53 antioxidant function is dependent on its transcriptional activity and proceeds by seq...

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