Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

K, Maeda; I, Ieiri; K, Yasuda; A, Fujino; H, Fujiwara; K, Otsubo; M, Hirano; T, Watanabe; Y, Kitamura; H, Kusuhara; Y, Sugiyama

doi:10.1016/j.clpt.2006.01.011

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Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

Shared by NobleBlocks on Apr 11, 2006 • 12:00 AM UTC

Authors:

Maeda K

Ieiri I

Yasuda K

Abstract

<h4>Objective</h4>Recent reports have shown that genetic polymorphisms in organic anion transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs. However, the impact of OATP1B1*1b alleles, the frequency of which is high in all ethnicities, on the pharmacokinetics of substr...

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