Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia.

Y, Furukawa; R, Kubota; M, Tara; S, Izumo; M, Osame

doi:10.1182/blood.v97.4.987

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Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia.

Shared by NobleBlocks on Feb 1, 2001 • 12:00 AM UTC

Authors:

Furukawa Y

Kubota R

Tara M

Abstract

Although Tax protein is the main target of cytotoxic T lymphocyte (CTL) on human T-cell lymphotropic virus type I (HTLV-I)-infected cells, and Tax peptide 11 through 19 binding to HLA-A*02 has been shown to elicit a strong CTL response, there are patients with adult T-cell leukemia (ATL) bearing HLA...

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