Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

Glowacka, Ilona; Bertram, Stephanie; Herzog, Petra; Pfefferle, S.; Steffen, Imke; Muench, M.; Simmons, G.; Hofmann, Heike; Kuri, Thomas; Weber, F.; Eichler, J.; Drosten, C.; Pöhlmann, S.

doi:10.1128/JVI.01248-09

Public

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

Shared by NobleBlocks on Jan 15, 2010 • 12:00 AM UTC

Authors:

Ilona Glowacka

Stephanie Bertram

Petra Herzog

Abstract

ABSTRACT The human coronaviruses (CoVs) severe acute respiratory syndrome (SARS)-CoV and NL63 employ angiotensin-converting enzyme 2 (ACE2) for cell entry. It was shown that recombinant SARS-CoV spike protein (SARS-S) downregulates ACE2 expression and thereby promotes lung injury. Whether NL63-S exe...

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