Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

Jeanne Weiler, Ivan; A. Irwin, Scott; Y. Klintsova, Anna; M. Spencer, Corinne; D. Brazelton, Anthony; Miyashiro, Kevin; A. Comery, Thomas; Patel, Bindu; Eberwine, James; T. Greenough, William

doi:10.1073/pnas.94.10.5395

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Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

Shared by NobleBlocks on May 13, 1997 • 12:00 AM UTC

Authors:

Ivan Jeanne Weiler

Scott A. Irwin

Anna Y. Klintsova

Abstract

Local translation of proteins in distal dendrites is thought to support synaptic structural plasticity. We have previously shown that metabotropic glutamate receptor (mGluR1) stimulation initiates a phosphorylation cascade, triggering rapid association of some mRNAs with translation machinery near s...

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