Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.

SS, Baroni; M, Santillo; F, Bevilacqua; M, Luchetti; T, Spadoni; M, Mancini; P, Fraticelli; P, Sambo; A, Funaro; A, Kazlauskas; EV, Avvedimento; A, Gabrielli

doi:10.1056/nejmoa052955

Public

Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.

Shared by NobleBlocks on Jun 1, 2006 • 12:00 AM UTC

Authors:

Baroni SS

Santillo M

Bevilacqua F

Abstract

<h4>Background</h4>Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulate...

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