Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

AP, Hollander; I, Pidoux; A, Reiner; C, Rorabeck; R, Bourne; AR, Poole

doi:10.1172/jci118357

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Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

Shared by NobleBlocks on Dec 1, 1995 • 12:00 AM UTC

Authors:

Hollander AP

Pidoux I

Reiner A

Abstract

Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. Poole. 1994. J. Clin. Invest. 93:1722-1732). Using the same a...

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