Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly.

K, Miyachi; Y, Hirano; T, Horigome; T, Mimori; H, Miyakawa; Y, Onozuka; M, Shibata; M, Hirakata; A, Suwa; H, Hosaka; S, Matsushima; T, Komatsu; H, Matsushima; RW, Hankins; MJ, Fritzler

doi:10.1111/j.1365-2249.2004.02456.x

Public

Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly.

Shared by NobleBlocks on Jun 1, 2004 • 12:00 AM UTC

Authors:

Miyachi K

Hirano Y

Horigome T

Abstract

We have reported previously that p95c, a novel 95-kDa cytosolic protein, was the target of autoantibodies in sera of patients with autoimmune hepatic diseases. We studied 30 sera that were shown previously to immunoprecipitate a 95 kDa protein from [(35)S]-methionine-labelled HeLa lysates and had a ...

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